@article{Alvarez-Barreto_Viteri Narvaez_Proaño Aviles_Caicedo Páliz_Grunauer Andrade_Eguiguren_Vargas_2021, title={Development of Films, Based on Oxidized Ipomea Batatas Starch, with Protein Encapsulation}, volume={42}, url={http://rmib.mx/index.php/rmib/article/view/1171}, DOI={10.17488/RMIB.42.2.10}, abstractNote={<p>Oxidized or dialdehyde starches (DAS) have been used as biomaterials due to their biocompatibility and biodegradability; nonetheless, sweet potato (<em>Ipomea batatas L.</em>) starch has not been researched in this field. Films based on sweet potato DAS, mixed with native starch (NS), poly-vinyl alcohol (PVA) and glycerin have been developed to encapsulate a model protein (Bovine serum albumin, BSA), using central composite design (CCD) and surface methodology (RSM). Input variables were oxidation degree, NS concentration and polymeric mixture volume, while output variables were film´s thickness, equilibrium swelling and BSA release. DAS was obtained through hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) oxidation, and the oxidation degree is referred to as H<sub>2</sub>O<sub>2</sub> concentration. Scanning electron microscopy revealed a rough surface, and formulations containing 10% H<sub>2</sub>O<sub>2</sub> DAS presented micropores. Water uptake was greater with DAS than native starch, due to its hydroxyl groups shown in Fourier transformed infrared spectra. Fil thickness depended on the volume of the polymeric suspension and influenced the swelling capacity; thicker films absorbed less water. According to RSM, the optimal formulation was DAS with 5% H<sub>2</sub>O<sub>2</sub> and 35% NS. Oxidized sweet potato starch has potential for biomaterial applications, as films developed with it can encapsulate a protein and release it in a controlled fashion.</p>}, number={2}, journal={Revista Mexicana de Ingenieria Biomedica}, author={Alvarez-Barreto, José and Viteri Narvaez, Daniela and Proaño Aviles, Juan Sebastian and Caicedo Páliz, Andrés Bernando and Grunauer Andrade, Michelle Amanda and Eguiguren, Luis Ricardo and Vargas, Michel}, year={2021}, month={Jul.}, pages={119–131} }