Determination of early bone metastasis on Bone Scans Using the Gray Levels Histogram

  • Mónica Pérez Meza Universidad de la Sierra Sur
  • Alberto Jaramillo Núñez Instituto Nacional de Astrofísica Óptica y Electrónica
  • Bolivia Cuevas Otahola Benemérita Universidad Autónoma de Puebla Facultad de Ciencias de la Electrónica
  • Jesús Alonso Arriaga Hernández Benemérita Universidad Autónoma de Puebla Facultad de Ciencias Físico Matemáticas
  • Bárbara Emma Sánchez Rinza Benemérita Universidad Autónoma de Puebla
Keywords: Bone scan, Skeletal metastasis, Image histogram, Digital image processing


The aim of this paper is to show a technique to speed up the interpretation of bone scans in order to determine the presence of early bone metastasis. This is done using the gray levels histogram of the region of interest. The technique is intended to assist in the bone scans interpretation in order to provide a successful diagnosis. During the analysis, three types of histograms were observed on the regions of interest. If the histogram is narrow and shifted toward the origin, the bone scan is free of metastasis.  If it is shifted to the right and slightly broadened, indicates the presence of a bone anomaly different from a metastasis. On the other hand, if the histogram is more broadened and shifted to the right, is suggests the presence of metastasis. This histogram is characterized by displaying small curls on the right side providing information about the metastatic disease stage, which could be low-amplitude peaks and have a short length, if the metastasis is in early stage, or high-amplitude peaks and a long length, if is advanced.  Finally, the analyzed region is displayed in false color considering the minimum gray levels observed in the histogram.


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How to Cite
Pérez Meza, M., Jaramillo Núñez, A., Cuevas Otahola, B., Arriaga Hernández, J. A., & Sánchez Rinza, B. E. (2021). Determination of early bone metastasis on Bone Scans Using the Gray Levels Histogram. Mexican Journal of Biomedical Engineering, 42(2), 6-14. Retrieved from
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