@article{Pérez Bonilla_Reyes Monreal_Pérez Escalera_Reyes Lazalde_2020, title={Set of Simulators of the Electrophysiology of the A-Type Potassium Current (IA) in Neurons}, volume={41}, url={https://rmib.mx/index.php/rmib/article/view/1059}, DOI={10.17488/RMIB.41.3.2}, abstractNote={<p><span class="fontstyle0">The A-type potassium current (I</span><span class="fontstyle0" style="font-size: 6pt;">A</span><span class="fontstyle0">) participates in important brain functions, including neuronal excitability, synaptic integration, and regulation of action potential patterns and fring frequency. Based on the characterization of its electrophysiological properties by current and voltage clamp techniques, mathematical models have been developed that reproduce I</span><span class="fontstyle0" style="font-size: 6pt;">A </span><span class="fontstyle0">function. For such models, it is necessary to numerically solve equations and utilize hardware with special speed and performance characteristics. Since specifc software for studying I</span><span class="fontstyle0" style="font-size: 6pt;">A </span><span class="fontstyle0">is not found on the Internet, the aim of this work was to develop a set of simulators grouped into three computer programs: (1) I</span><span class="fontstyle0" style="font-size: 6pt;">A </span><span class="fontstyle0">Current, (2) I</span><span class="fontstyle0" style="font-size: 6pt;">A </span><span class="fontstyle0">Constant-V Curves and (3) I</span><span class="fontstyle0" style="font-size: 6pt;">A </span><span class="fontstyle0">AP Train. These simulators provide a virtual reproduction of experiments on neurons with the possibility of setting the current and voltage, which allows for the study of the electrophysiological and biophysical characteristics of I</span><span class="fontstyle0" style="font-size: 6pt;">A </span><span class="fontstyle0">and its eﬀect on the train of action potentials. The mathematical models employed were derived from the work of Connor </span><span class="fontstyle2">et al</span><span class="fontstyle0">., giving rise to Hodgkin-Huxley type models. The programs were developed in Visual Basic® and the diﬀerential equation systems were simultaneously solved numerically. The resulting system represents a breakthrough in the ability to replicate I</span><span class="fontstyle0" style="font-size: 6pt;">A </span><span class="fontstyle0">activity in neurons.</span></p>}, number={3}, journal={Revista Mexicana de Ingenieria Biomedica}, author={Pérez Bonilla, María Eugenia and Reyes Monreal, Marleni and Pérez Escalera, Miguel Felipe and Reyes Lazalde, Arturo}, year={2020}, month={Oct.}, pages={28–39} }