Análisis estadístico de los espectros de frecuencia de las regiones reguladoras del ENCODE

O. Paredes; R. Romo-Vázquez; H. Vélez-Pérez; J. A. Morales

doi:10.17488/RMIB.38.3.10

Statistical analysis of the Fourier Spectra of the ENCODE regulatory regions

Authors

O. Paredes Maestría en Ciencias en Ingeniería Electrónica y Computación, CUCEI, Universidad de Guadalajara
R. Romo-Vázquez Departamento de Ciencias Computacionales, CUCEI, Universidad de Guadalajara
H. Vélez-Pérez Departamento de Ciencias Computacionales, CUCEI, Universidad de Guadalajara
J. A. Morales Departamento de Ciencias Computacionales, CUCEI, Universidad de Guadalajara

DOI:

https://doi.org/10.17488/RMIB.38.3.10

Keywords:

genomic signal processing, ENCODE, frequency spectrum, statistical moments, Fourier transform

Abstract

Nowadays, new genomic databases (DNA sequences) are available to the whole scientist community for its analysis. The bioinformatics has developed algorithms to extract information and features of the sequences. However, the bioinformatics algorithms have restrictions. An alternative is the use of digital signal processing (DSP) tools adap-ted to genomic sequences (genomic signal processing – GSP). This work analyzes the first four statistics moments (mean, standard deviation, skewness and kurtosis) and other two moments (median and variance) of the frequency spectra of 15 regulatory regions (RRs) in ENCODE database with the main objective of studying the statistics di-fferences and frequency features. The selected database is mapped. Then, the FFT is calculated to these genomic signals and finally the statistic moments implemented. The results show a three-group behavior in the RRs with the mean, median and kurtosis. The deviations standard and the variance do not show important behavior. Finally, the skewness shows a homogeneous behavior with the lack of atypical values in some RRs. These observations support the idea of the presence of periodicities in a sequence that may be related or may determine the biological function that a sequence may perform.

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Published

2017-09-14

How to Cite

Paredes, O., Romo-Vázquez, R., Vélez-Pérez, H., & Morales, J. A. (2017). Statistical analysis of the Fourier Spectra of the ENCODE regulatory regions. Revista Mexicana De Ingenieria Biomedica, 38(3), 637–645. https://doi.org/10.17488/RMIB.38.3.10

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Issue

Vol. 38 No. 3 (2017)

Section

Special Issue

License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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